Macromedia's Contribute
Macromedia has released a trial version and QuickTime videos of it's newest app, cleverly named Contribute. It looks pretty cool, though I don't know many business types who want to edit/update their own website. They usually prefer to just have someone do the updates for them. I think it'll flop unless it's super cheap - like $50 or something.
Update: I found a good review here.
Update 2: Zeldman says $99 bucks.